Abstract: International audience; DDE Transposons have been recruited at least four times as site-specific recombination activating gene allowing programmed DNA elimination in eukaryotes. The described cases are RAG in jawed vertebrates, Kat 1 and Alpha 3 in the Kluyveromyces lactis yeast and Piggymac/TPB1 TPB2 and TPB6 in ciliates. The domesticated RAG is the most known case. It constitutes the enzymatic core of the Jawed vertebrates V(D)J recombination machinery. It directs random assembly and joining of gene segments during the development of B and T ...
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Topics: 
Genetics
Evolutionary biology