Abstract: compounds often lead to hyperplasia of hepatocytes. Therefore, the novel method presented by Hammad and colleagues provides a potentially powerful tool to quantify aspects of liver microarchitecture that could prove indispensable in toxicological pathology. Currently, much effort is being invested into the establishment of alternative methods to characterize organ toxicity (Godoy et al. 2009, 2013; Godoy 2011; Hammad et al. 2013, 2014; Hengstler et al. 2012; Hewitt et al. 2007; Schug et al. 2013; Rodrigues et al. 2013; Messner et al. 2013; Bolt...
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