Abstract: where it induces transcription of a number of cytoprotec-tive genes.In their comprehensive review, Baird and Dinkova-Kostova (2011) present different models of regulation, such as the ‘sequester and release model’ for Keap1-Nrf2, the role of cullin 3 during dissociation, the hinge and latch model, sensing of inducers by Nrf2 and the role of phosphorylation. Moreover, a comprehensive overview of cytoprotective Nrf2 target genes and the chemistry of inducers are provided. In a complementary review, Slo-cum and Kensler (2011) focus on genetic ...
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Cancer research