Abstract: Identification of toxic mechanisms by test compoundinduced gene expression alterations is one of the major topics in current toxicological research (Ellinger-Ziegelbauer et al. 2008; Yamauchi et al. 2011; Bolt et al. 2010; Shimada et al. 2010; Adler et al. 2011; Heise et al. 2012). Also, a great deal of effort has been invested to optimize cell systems for gene array analyses in vitro (Godoy et al. 2009, 2010a, b; Zellmer et al. 2010; Hoehme et al. 2010). Recently, Schmidt and colleagues have introduced a technique that substantially facilitate...
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Computational biology